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Análisis sistémico IN SILICO de la expresión diferencial de genes localizados en la región crítica del síndrome de Down (DSCR) en el cerebro humano

dc.creatorMontoya Villegas, Julio César
dc.creatorPeña González, Ángela
dc.creatorSatizábal Soto, José María
dc.creatorGarcía-Vallejo, Felipe
dc.date2012-01-29
dc.identifierhttps://revistas.unimilitar.edu.co/index.php/rmed/article/view/1197
dc.identifier10.18359/rmed.1197
dc.descriptionUno de los retos más importantes de este siglo en la neurología genómica es construir mapas de expresión espacial de genes a lo largo de las distintas estructuras cerebrales con el fin de correlacionarlos con ciertas neuropatologías. Se analizaron los perfiles de transcripción de ocho genes HAS21 localizados en la región crítica del síndrome de Down en diferentes estructuras del cerebro humano normal. Se tomaron como referencia los valores de expresión de ocho genes HAS21/DSCR provenientes de experimentos de micromatrices de ADN de cerebros humanos normales y cuyos valores están disponibles en la base de datos del proyecto cerebro humano del Atlas del Cerebro del Allen Institute for Brain Sciences en Seattle, Washington (http://www.brain-map.org). Se determinó una expresión diferencial de estos genes HAS21/DSCR a lo largo de las estructuras localizadas en el lóbulo frontal, el lóbulo límbico y en los núcleos centrales. En el putamen, el núcleo caudado, el giro parahipocampal y en las áreas centrales se registraron los mayores niveles de transcripción global; estas áreas del cerebro parecen estar asociadas con diversos procesos de aprendizaje y de memoria. Se correlacionó la transcripción diferencial de genes DSCR con la localización cerebral y su potencial papel funcional.es-ES
dc.formatapplication/pdf
dc.languagespa
dc.publisherUniversidad Militar Nueva Granadaes-ES
dc.relationhttps://revistas.unimilitar.edu.co/index.php/rmed/article/view/1197/917
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dc.rightsDerechos de autor 2015 Revista Medes-ES
dc.sourceRevista Med; Vol. 20 No. 1 (2012): january - june; 15-26en-US
dc.sourceRevista Med; Vol. 20 Núm. 1 (2012): enero - junio; 15-26es-ES
dc.source1909-7700
dc.source0121-5256
dc.subjectanálisis de micromatriceses-ES
dc.subjectperfilación de la expresión génicaes-ES
dc.subjectbiología computacionales-ES
dc.subjectcerebroes-ES
dc.subjectsíndrome de Downes-ES
dc.titleAnálisis sistémico IN SILICO de la expresión diferencial de genes localizados en la región crítica del síndrome de Down (DSCR) en el cerebro humanoes-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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