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dc.contributor.advisorCotes, Marthaspa
dc.contributor.authorRugeles, Jorge Andres
dc.contributor.authorCotes, Martha
dc.coverage.spatialMedicinaspa
dc.date.accessioned2015-10-05T19:08:51Z
dc.date.accessioned2019-12-30T19:05:46Z
dc.date.available2015-10-05T19:08:51Z
dc.date.available2019-12-30T19:05:46Z
dc.date.issued2015-06-07
dc.identifier.urihttp://hdl.handle.net/10654/6663
dc.description.abstractObjetivo: Describir las características sociodemográficas, clínicas, complicaciones, supervivencia global y libre de enfermedad y adherencia al tratamiento en pacientes con cáncer escamocelular de cabeza y cuello, tratados con radioterapia externa técnica conformacional (3DCRT) o radioterapia de intensidad modulada (IMRT) en el Instituto Nacional de Cancerología, entre el periodo de enero 1 del 2005 y diciembre 31 del 2012. Métodos: Estudio de series de casos en pacientes con cancer de cabeza y cuello tratados con radioterapia externa tecnica 3D-CRT y de intensidad modulada (IMRT), se emplearon medidas de tendencia central y dispersión para las variables numéricas y frecuencias simples y porcentajes para las variables categóricas. Para el análisis de supervivencia se empleó el método de Kaplan-Meier en la descripción de la supervivencia y el modelo de regresión de Cox para el análisis multivariable Resultados: Se incluyeron 49 pacientes con cáncer de cabeza y cuello que fueron atendidos entre enero de 2005 y diciembre 2012, y que fueron tratados con radioterapia con técnica conformacional (3DCRT) o radioterapia de intensidad modulada (IMRT), se observó adherencia en 85% de los pacientes, principalmente en aquellos tratados con IMRT (64,3 %) en comparación con los pacientes que recibieron terapia conformacional (37,7 %). Solo fueron analizados 32 pacientes (65,3 %) para la supervivencia libre de recaída, debido a que los 17 pacientes restantes no tenía información registrada en las historias clínicas. No fue posible calcular la mediana de supervivencia, la tasa de recaída fue de 4,6 por cada 1000/año (IC=95% 1,9 a 11,1). Conclusiones: El seguimiento fue corto y limita la posibilidad de realizar comparaciones con series internacionales, las variables asociadas a peligro de muerte concuerdan con las reportadas en la literatura internacional, la única variable que presenta asociación estadística con la supervivencia es el estadio clínico global y en cuanto a la toxicidad se evidencia una tendencia a mayor toxicidad con tecnica 3D-CRT por lo que se recomienda tratar a los pacientes con tecnica IMRT para disminuir la toxicidad del tratamiento.spa
dc.description.sponsorshipNingunospa
dc.formatpdfspa
dc.language.isospaspa
dc.publisherUniversidad Militar Nueva Granadaspa
dc.titleExperiencia en el tratamiento con radioterapia conformacional y de intensidad modulada en pacientes con tumores de cabeza y cuello en el Instituto Nacional de Cancerologíaspa
dc.typeinfo:eu-repo/semantics/bachelorThesisspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.subject.lembRADIOTERAPIAspa
dc.subject.lembNEOPLASMAS DE CABEZA Y CUELLOspa
dc.subject.lembCANCER-RADIOTERAPIAspa
dc.publisher.departmentFacultad de Medicinaspa
dc.type.localTrabajo de gradospa
dc.description.abstractenglishObjective: To describe the sociodemographic and clinical characteristics, complications, and overall disease-free survival and adherence to treatment in patients with squamous cell cancer of the head and neck treated with conformal external radiotherapy technique (3DCRT) or intensity modulated radiotherapy (IMRT) in the National Cancer Institute, between the period of January 1, 2005 and December 31, 2012. Methods: case series study in patients with cancer of head and neck treated with external radiotherapy technique 3D-CRT and intensity modulated (IMRT), measures of central tendency and dispersion for simple numeric variables and frequencies and percentages were used for categorical variables. For the analysis of survival the Kaplan-Meier in the description of survival and Cox regression model for multivariate analysis was used Results: 49 patients with head and neck were treated between January 2005 and December 2012 cancer were included, and were treated with radiotherapy with conformal technique (3DCRT) or intensity modulated radiation therapy (IMRT), adhesion was observed in 85% patients, mainly in those treated with IMRT (64.3%) compared to patients receiving therapy conformational (37.7%). Only 32 patients were analyzed (65.3%) for relapse-free survival, because the remaining 17 patients had no information recorded in medical records. It was not possible to calculate the median survival, relapse rate was 4.6 per 1,000 / year (95% CI = 1.9 to 11.1). Conclusions: The follow-up was short and limited the possibility of making comparisons with international series, the variables associated with risk of death match those reported in international literature, the only variable that presented statistical association with survival is the global clinical stage and for toxicity is a tendency to increased toxicity with 3D-CRT technique so it is recommended to treat patients with IMRT technique to reduce treatment toxicity.eng
dc.title.translatedHead and neck neoplasms treated with conformal and Intensity-Modulated Radiotherapy in the Instituto Nacional de Cancerologiaspa
dc.subject.keywordsHead and neck neoplasmsspa
dc.subject.keywordsConformal Radiotherapyspa
dc.subject.keywordsIntensity-Modulated Radiotherapyspa
dc.publisher.programOncología Radioterápicaspa
dc.creator.degreenameEspecialista en Oncología Radioterápicaspa
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dc.subject.proposalNeoplasias de Cabeza y Cuellospa
dc.subject.proposalRadioterapia Conformalspa
dc.subject.proposalRadioterapia de Intensidad Moduladaspa


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